/* Clinical Evidence Page Styles */
  .evidence-hero {
    background: linear-gradient(135deg, var(--brand-primary) 0%, #1d4ed8 100%);
    padding: 100px 16px 80px;
    text-align: center;
    color: white;
  }

  .evidence-hero h1 {
    font-size: 48px;
    font-weight: 700;
    line-height: 56px;
    margin-bottom: 16px;
    color: white;
  }

  .evidence-hero p {
    font-size: 20px;
    line-height: 32px;
    max-width: 700px;
    margin: 0 auto;
    opacity: 0.95;
  }

  .evidence-container {
    max-width: 1200px;
    margin: 0 auto;
    padding: 64px 16px;
  }

  /* Research Timeline */
  .timeline-section {
    padding: 80px 0;
    background: white;
  }

  .timeline-section h2 {
    font-size: 36px;
    font-weight: 700;
    color: var(--brand-dark);
    margin-bottom: 48px;
    text-align: center;
  }

  .timeline {
    position: relative;
    padding: 40px 0;
  }

  .timeline::before {
    content: '';
    position: absolute;
    left: 50%;
    top: 0;
    bottom: 0;
    width: 4px;
    background: linear-gradient(180deg, var(--brand-primary) 0%, var(--brand-accent) 100%);
    transform: translateX(-50%);
  }

  .timeline-item {
    position: relative;
    margin-bottom: 60px;
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 60px;
    align-items: center;
  }

  .timeline-item:nth-child(even) .timeline-content {
    order: -1;
  }

  .timeline-dot {
    position: absolute;
    left: 50%;
    top: 50%;
    transform: translate(-50%, -50%);
    width: 24px;
    height: 24px;
    background: var(--brand-primary);
    border: 6px solid white;
    border-radius: 50%;
    box-shadow: 0 0 0 4px var(--brand-primary);
    z-index: 10;
  }

  .timeline-dot.featured {
    width: 32px;
    height: 32px;
    background: var(--brand-accent);
    box-shadow: 0 0 0 6px var(--brand-accent);
  }

  .timeline-content {
    background: white;
    padding: 32px;
    border-radius: 12px;
    box-shadow: 0 4px 16px rgba(0,0,0,0.1);
    transition: all 0.3s ease;
  }

  .timeline-content:hover {
    transform: translateY(-4px);
    box-shadow: 0 8px 24px rgba(0,0,0,0.15);
  }

  .timeline-year {
    font-size: 48px;
    font-weight: 700;
    color: var(--brand-neutral);
    opacity: 0.3;
    text-align: right;
  }

  .timeline-item:nth-child(even) .timeline-year {
    text-align: left;
  }

  .timeline-label {
    display: inline-block;
    padding: 6px 16px;
    background: var(--medical-green-light);
    color: var(--brand-accent);
    border-radius: 20px;
    font-size: 14px;
    font-weight: 600;
    margin-bottom: 12px;
  }

  .timeline-label.nobel {
    background: #fef3c7;
    color: #f59e0b;
  }

  .timeline-content h3 {
    font-size: 24px;
    font-weight: 600;
    color: var(--brand-primary);
    margin-bottom: 12px;
  }

  .timeline-content p {
    font-size: 16px;
    line-height: 26px;
    color: var(--brand-dark);
    margin-bottom: 0;
  }

  /* Studies Grid */
  .studies-section {
    padding: 80px 0;
    background: var(--medical-gray);
  }

  .studies-section h2 {
    font-size: 36px;
    font-weight: 700;
    color: var(--brand-dark);
    margin-bottom: 16px;
    text-align: center;
  }

  .studies-section .section-subtitle {
    font-size: 18px;
    color: var(--brand-neutral);
    text-align: center;
    margin-bottom: 48px;
  }

  .studies-grid {
    display: grid;
    grid-template-columns: repeat(6, 1fr);
    gap: 32px;
    justify-items: stretch;
  }

  .study-card {
    background: white;
    border-radius: 12px;
    padding: 32px;
    box-shadow: 0 4px 16px rgba(0,0,0,0.08);
    transition: all 0.3s ease;
    border-left: 4px solid var(--brand-primary);
    display: flex;
    flex-direction: column;
    grid-column: span 2;
  }

  /* Center last 2 cards on desktop (row 2) - using 6 column grid */
  .study-card:nth-child(4) {
    grid-column: 2 / 4;
  }

  .study-card:nth-child(5) {
    grid-column: 4 / 6;
  }

  .study-card.featured {
    border-left-color: var(--brand-accent);
    border-left-width: 6px;
    background: linear-gradient(135deg, #ffffff 0%, var(--medical-blue-light) 100%);
  }

  .study-card:hover {
    transform: translateY(-4px);
    box-shadow: 0 8px 24px rgba(0,0,0,0.12);
  }

  .study-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 16px;
  }

  .study-year {
    font-size: 18px;
    font-weight: 700;
    color: var(--brand-primary);
  }

  .study-badge {
    padding: 4px 12px;
    background: var(--medical-green-light);
    color: var(--brand-accent);
    border-radius: 12px;
    font-size: 12px;
    font-weight: 600;
    text-transform: uppercase;
  }

  .study-badge.featured {
    background: #fef3c7;
    color: #f59e0b;
  }

  .study-card h3 {
    font-size: 22px;
    font-weight: 600;
    color: var(--brand-dark);
    margin-bottom: 12px;
    line-height: 1.3;
  }

  .study-authors {
    font-size: 14px;
    color: var(--brand-neutral);
    margin-bottom: 8px;
  }

  .study-publication {
    font-size: 14px;
    font-style: italic;
    color: var(--brand-neutral);
    margin-bottom: 16px;
  }

  .key-finding {
    background: var(--medical-blue-light);
    padding: 20px;
    border-radius: 8px;
    margin: 20px 0;
    flex: 1;
    display: flex;
    flex-direction: column;
  }

  .key-finding strong {
    display: block;
    font-size: 14px;
    color: var(--brand-primary);
    margin-bottom: 8px;
    text-transform: uppercase;
    letter-spacing: 0.05em;
  }

  .key-finding p {
    font-size: 16px;
    line-height: 26px;
    color: var(--brand-dark);
    margin: 0;
  }

  .study-actions {
    display: flex;
    gap: 12px;
    margin-top: auto;
    padding-top: 20px;
  }

  .btn-secondary {
    padding: 12px 24px;
    background: var(--brand-accent);
    color: white;
    border-radius: 6px;
    font-size: 14px;
    font-weight: 600;
    text-decoration: none;
    transition: all 0.3s ease;
    display: inline-block;
  }

  .btn-secondary:hover {
    background: #059669;
    transform: translateY(-2px);
    box-shadow: 0 4px 12px rgba(16,185,129,0.3);
  }

  .btn-outline {
    padding: 12px 24px;
    background: transparent;
    color: var(--brand-primary);
    border: 2px solid var(--brand-primary);
    border-radius: 6px;
    font-size: 14px;
    font-weight: 600;
    text-decoration: none;
    transition: all 0.3s ease;
    display: inline-block;
  }

  .btn-outline:hover {
    background: var(--brand-primary);
    color: white;
  }

  /* Dr. Burke Section */
  .advisor-section {
    background: white;
    padding: 80px 0;
  }

  .advisor-content {
    max-width: 1200px;
    margin: 0 auto;
    padding: 0 16px;
    display: grid;
    grid-template-columns: 200px 1fr;
    gap: 40px;
    align-items: center;
  }

  .advisor-image {
    width: 200px;
    height: 200px;
    border-radius: 50%;
    overflow: hidden;
    box-shadow: 0 8px 24px rgba(0,0,0,0.15);
  }

  .advisor-image img {
    width: 100%;
    height: 100%;
    object-fit: cover;
  }

  .advisor-bio h2 {
    font-size: 32px;
    font-weight: 700;
    color: var(--brand-dark);
    margin-bottom: 8px;
  }

  .advisor-title {
    font-size: 18px;
    color: var(--brand-primary);
    font-weight: 600;
    margin-bottom: 24px;
  }

  .advisor-bio ul {
    list-style: none;
    padding: 0;
    margin: 0;
  }

  .advisor-bio li {
    font-size: 16px;
    color: var(--brand-dark);
    padding: 8px 0;
    padding-left: 32px;
    position: relative;
  }

  .advisor-bio li:before {
    content: "✓";
    position: absolute;
    left: 0;
    color: var(--brand-accent);
    font-weight: 700;
    font-size: 20px;
  }

  /* Downloads Section */
  .downloads-section {
    background: var(--medical-gray);
    padding: 80px 0;
  }

  .downloads-section h2 {
    font-size: 28px;
    font-weight: 700;
    color: var(--brand-dark);
    margin-bottom: 32px;
    text-align: center;
  }

  .downloads-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 24px;
    max-width: 1200px;
    margin: 0 auto;
    padding: 0 16px;
  }

  .download-item {
    display: flex;
    align-items: center;
    gap: 16px;
    padding: 20px;
    background: var(--brand-light);
    border-radius: 8px;
    border: 1px solid #e2e8f0;
    transition: all 0.3s ease;
    text-decoration: none;
    color: inherit;
  }

  .download-item:hover {
    background: var(--medical-blue-light);
    border-color: var(--brand-primary);
    transform: translateX(4px);
  }

  .download-icon {
    width: 48px;
    height: 48px;
    background: var(--brand-primary);
    color: white;
    border-radius: 8px;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 24px;
    flex-shrink: 0;
  }

  .download-info h4 {
    font-size: 16px;
    font-weight: 600;
    color: var(--brand-dark);
    margin: 0 0 4px 0;
  }

  .download-info p {
    font-size: 14px;
    color: var(--brand-neutral);
    margin: 0;
  }

  /* CTA Section */
  .evidence-cta {
    background: linear-gradient(135deg, var(--brand-primary) 0%, #1d4ed8 100%);
    padding: 80px 32px;
    text-align: center;
    color: white;
    border-radius: 16px;
    max-width: 1200px;
    margin: 0 auto;
  }

  .evidence-cta h2 {
    font-size: 36px;
    font-weight: 700;
    color: white;
    margin-bottom: 16px;
  }

  .evidence-cta p {
    font-size: 18px;
    line-height: 28px;
    color: rgba(255,255,255,0.95);
    max-width: 600px;
    margin: 0 auto 32px;
  }

  .evidence-cta .btn-primary {
    background: white;
    color: var(--brand-primary);
    padding: 16px 40px;
    font-size: 18px;
    font-weight: 600;
    border-radius: 8px;
    text-decoration: none;
    display: inline-block;
    transition: all 0.3s ease;
  }

  .evidence-cta .btn-primary:hover {
    background: var(--medical-blue-light);
    transform: translateY(-2px);
    box-shadow: 0 8px 20px rgba(255,255,255,0.3);
  }

  /* Responsive - Tablet: 2-2-1 layout */
  @media (max-width: 1024px) {
    .studies-grid {
      grid-template-columns: repeat(4, 1fr);
      gap: 24px;
    }

    .study-card {
      grid-column: span 2;
    }

    /* Reset desktop specific positioning */
    .study-card:nth-child(4),
    .study-card:nth-child(5) {
      grid-column: span 2;
    }

    /* Center last card (5th) on tablet - spans 2 columns starting at column 2 */
    .study-card:nth-child(5) {
      grid-column: 2 / 4;
    }
  }

  @media (max-width: 768px) {
    .evidence-hero h1 {
      font-size: 32px;
      line-height: 40px;
    }

    .evidence-hero p {
      font-size: 16px;
    }

    .timeline::before {
      left: 20px;
    }

    .timeline-item {
      grid-template-columns: 1fr;
      padding-left: 60px;
      gap: 16px;
    }

    .timeline-dot {
      left: 20px;
    }

    .timeline-year {
      font-size: 32px;
      text-align: left !important;
      margin-bottom: 0;
      order: 1;
    }

    .timeline-content {
      order: 2;
      padding: 24px;
    }

    /* Reset even item ordering on mobile */
    .timeline-item:nth-child(even) .timeline-content {
      order: 2;
    }

    .timeline-item:nth-child(even) .timeline-year {
      order: 1;
    }

    /* Studies Section Mobile Fix */
    .studies-section {
      padding: 60px 0;
      overflow-x: hidden;
    }

    .evidence-container {
      padding: 0 16px;
      max-width: 100%;
    }

    .studies-section h2 {
      font-size: 28px;
      padding: 0 16px;
    }

    .studies-section .section-subtitle {
      font-size: 16px;
      padding: 0 16px;
    }

    .studies-grid {
      grid-template-columns: 1fr !important;
      gap: 24px;
      padding: 0 16px;
    }

    .study-card {
      grid-column: 1 / -1 !important;
      padding: 24px;
      margin: 0;
      width: 100%;
      box-sizing: border-box;
    }

    /* Reset all nth-child rules on mobile */
    .study-card:nth-child(4),
    .study-card:nth-child(5) {
      grid-column: 1 / -1 !important;
    }

    .study-card h3 {
      font-size: 20px;
    }

    .study-actions {
      flex-direction: column;
      gap: 8px;
    }

    .btn-secondary,
    .btn-outline {
      width: 100%;
      text-align: center;
    }

    /* Advisor Section Mobile */
    .advisor-content {
      grid-template-columns: 1fr;
      text-align: center;
    }

    .advisor-image {
      margin: 0 auto;
    }

    .advisor-bio h2 {
      font-size: 24px;
    }

    .advisor-title {
      font-size: 16px;
    }

    .advisor-bio li {
      font-size: 14px;
      text-align: left;
    }
  }